Both the A6 and LS have child safety locks to prevent children from opening the rear doors. The A6 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The LS’ child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the A6 are reminded to check the back seat if they opened the rear door before starting out. The LS doesn’t offer a back seat reminder.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The A6 has Car-to-X Services, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The LS doesn’t offer a system that can receive automated systems from infrastructure.
Both the A6 and the LS have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available around view monitors.

